Mechanism of Selective Urea Permeation through a Bacterial Urea Transporter
نویسندگان
چکیده
منابع مشابه
Structure and permeation mechanism of a mammalian urea transporter.
As an adaptation to infrequent access to water, terrestrial mammals produce urine that is hyperosmotic to plasma. To prevent osmotic diuresis by the large quantity of urea generated by protein catabolism, the kidney epithelia contain facilitative urea transporters (UTs) that allow rapid equilibration between the urinary space and the hyperosmotic interstitium. Here we report the first X-ray cry...
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Urea transporter B (UT-B) is a membrane channel protein that specifically transports urea. UT-B null mouse exhibited urea selective urine concentrating ability deficiency, which suggests the potential clinical applications of the UT-B inhibitors as novel diuretics. Primary high-throughput virtual screening (HTVS) of 50000 small-molecular drug-like compounds identified 2319 hit compounds. These ...
متن کاملUrea may regulate urea transporter protein abundance during osmotic diuresis.
Rats with diabetes mellitus have an increase in UT-A1 urea transporter protein abundance and absolute urea excretion, but the relative amount (percentage) of urea in total urinary solute is actually decreased due to the marked glucosuria. Urea-specific signaling pathways have been identified in mIMCD3 cells and renal medulla, suggesting the possibility that changes in the percentage or concentr...
متن کاملMechanism of Urea Excretion
1. Urea is present in the cells of the proximal convoluted tubule in a concentration higher than that of the blood or than that of the cells of any of the other kidney tubules. 2. Such a condition can only be reconciled to an assumption of an active secretion (excretion) on the part of these cells. 3. Urea also passes through the glomerular filter with the other crystalloids of the blood plasma...
متن کاملEnergetic and Molecular Water Permeation Mechanisms of the Human Red Blood Cell Urea Transporter B
Urea transporter B (UT-B) is a passive membrane channel that facilitates highly efficient permeation of urea. In red blood cells (RBC), while the major function of UT-B is to transport urea, it is assumed that this protein is able to conduct water. Here, we have revisited this last issue by studying RBCs and ghosts from human variants with defects of aquaporin 1 (AQP1) or UT-B. We found that UT...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2010
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2009.12.3442